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A biotechnology catastrophe may be caused by accidentally releasing a genetically engineered organism from controlled environments, by the planned release of such an organism which then turns out to have unforeseen and catastrophic interactions with essential natural or agro-ecosystems, or by intentional usage of biological agents in biological warfare or bioterrorism attacks. Pathogens may be intentionally or unintentionally genetically modified to change virulence and other characteristics. For example, a group of Australian researchers unintentionally changed characteristics of the mousepox virus while trying to develop a virus to sterilize rodents. The modified virus became highly lethal even in vaccinated Trending flamingo tropical bedding set and naturally resistant mice. The technological means to genetically modify virus characteristics are likely to become more widely available in the future if not properly regulated. The Cambridge Project at Cambridge University says the “greatest threats” to the human species are man-made; they are artificial intelligence, global warming, nuclear war, and rogue biotechnology. The Future of Humanity Institute also states that human extinction is more likely to result from anthropogenic causes than natural causes.

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