improvement of tissue-engineered products that provide simple options to complicated problems. Nevertheless, we should also be thinking about knowing what the safety of immune-engineered biomaterials and their long-term efficacy will be. The management of neutrophil mobilization and capabilities could be an interesting strategy to promote/modulate tissue regeneration. They are the first circulating cells of the innate immune response migrating after tissue damage, likely involved in macrophage polarization, but it is still unknown how exactly this happens. Cytokines may be regionally delivered both by immobilization into the biomaterial
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